Is there a way to pick Scope/Flat bumpers and other intros based on screen ratio or aspect ratio?

You can create different sequences with aspect ratio as a condition.  

There is currently an issue with 2.2 and 2.35 aspect ratios being combined as 2.22.35 so that neither work.  This has been fixed in the dev version and will be available in the next official release.

That is based on the media content itself right? I was wondering based on screen ratio. Like I have to setups. One is 2.35 (Scope) and Another is 1.9 (Flat) Screen. So was wondering if it can be based on the display output.

I currently have sequences setup separately and also have different profiles for each setup to pick from different content path.

It isn't set up on the actual file.  

The sequence is prepared before the movie plays and is based off of the information that Kodi provides, so there's no way for PreShow to know what the exact ratio is based on the video unless Kodi knows that already.

You can either use Tiny Media Manager to create more detailed info for your files in Kodi or allow PreShow to pull the aspect ratio from IMDB, which adds a delay to the start of the sequence.